EMA/TMA Intermittent Issues

Update timeline

1. investigating Apr 27, 2026, 09:26 AM UTC

   We are currently experiencing some intermittent issues which means that you may experience an 401 error when trying to access the eTMA system. We are aware of this issue. Please try again by either refreshing the page or login via private browsing method e.g incognito mode. We are working to resolve the problem as quickly as we can. Please accept our apologies for any concern or inconvenience caused by this issue.

2. identified Apr 28, 2026, 02:47 PM UTC

   We've made some changes to hopefully improve the stability of the eTMA system. If you do encounter any issues whilst accessing/submitting TMAs please try again a few minutes later. We are continuing to work on a permanent solution and apologise for any inconvenience caused.

3. monitoring Apr 29, 2026, 05:49 PM UTC

   Additional work has been completed to try and help restore stability to the eTMA application. We are aware of the repeated issues recently and apologise for the inconvenience caused. We are continuing to monitor the situation and make the necessary changes and appreciate your patience during this time.

4. monitoring Apr 30, 2026, 11:43 AM UTC

   We’ve been monitoring this morning and don’t see any repeat of the errors we saw as part of our investigation into the recent issues with TMA submissions. At the time of posting this no new issues have been reported. With the exception of some delayed TMA submission emails which are been looked at separately but they are still going out, just delayed in some cases. We apologise for the inconvenience caused by these issues recently.